Table 3.
Univariate analysis overall survival and progression-free survival.
| Variables | Overall survival | Progression-free survival | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | |
| At diagnosis | ||||||
| Age > 45 years | 1.01 | 0.34–2.42 | 0.9 | 0.87 | 0.44–1.98 | 0.7 |
| Female versus male | 0.34 |
0.15–0.72 |
<0.004 |
0.62 | 0.34–1.10 | 0.1 |
| Albumin ≥ 4 | 0.30 |
0.14–0.61 |
<0.0009 |
0.38 | 0.21–0.69 | <0.001 |
| ALC ≥ 0.6 cells/µL | 0.12 |
0.06–0.24 |
<0.0001 |
0.25 | 0.14–0.45 | <0.0001 |
| Mediastinal ≥ 10 cm | 2.06 | 0.93–4.26 | 0.07 | 1.87 | 0.93–3.51 | 0.08 |
| Hemoglobin < 10.5 g/dL | 3.31 | 1.61–6.72 | <0.002 | 2.16 | 1.15–3.89 | <0.02 |
| Stage 4 | 1.14 | 0.52–2.86 | 0.3 | 1.37 | 0.71–2.51 | 0.3 |
| WBC > 15 cells/µL | 4.68 | 2.24–9.49 | <0.0001 | 3.18 | 1.64–5.84 | <0.001 |
| IPS ≥ 3 | 4.20 | 2.07–8.66 | <0.0001 | 2.89 | 1.59–5.14 | <0.0006 |
| Limited versus advanced stage | 0.92 | 0.45–1.86 | 0.8 | 0.73 | 0.40–1.30 | 0.3 |
| Infused CD34+ stem cells | 0.83 | 0.65–1.04 | 0.1 | 0.96 | 0.80–1.12 | 0.6 |
| Pretransplant response (CR versus PR) | 0.54 | 0.16–1.39 | 0.2 | 0.49 | 0.19–1.07 | 0.08 |
| At day 15 post-APBHSCT | ||||||
| ALC ≥ 0.5 cells/µL | 0.12 | 0.05–0.25 | <0.0001 | 0.21 | 0.11–0.37 | <0.0001 |
| At day 100 post-APBHSCT | ||||||
| Age, continuous | 0.99 | 0.97–1.03 | 0.9 | 0.95 | 0.87–1.11 | 0.5 |
| ALC, continuous | 0.33 | 0.16–0.61 | <0.0001 | 0.48 | 0.29–0.75 | <0.0006 |
| ALC ≥ 0.8 cells/µL | 0.28 | 0.15–0.59 | <0.0001 | 0.28 | 0.16–0.50 | <0.0001 |
| AMC, continuous | 2.16 | 1.46–2.92 | <0.0001 | 1.80 | 1.24–2.40 | <0.0001 |
| AMC ≥ 0.63 cells/µL | 7.55 | 3.64–15.93 | <0.0001 | 3.88 | 2.12–7.06 | <0.0001 |
| ALC/AMC, continuous | 0.03 | 0.01–0.10 | <0.0001 | 0.49 | 0.37–0.63 | <0.0001 |
| ALC/AMC ≥ 1.3 | 0.07 | 0.03–0.15 | <0.0001 | 0.18 | 0.10–0.32 | <0.0001 |
| ANC, continuous | 1.10 | 0.86–1.37 | 0.5 | 1.01 | 0.81–1.22 | 0.9 |
| Hgb, continuous | 0.93 | 0.76–1.13 | 0.5 | 0.96 | 0.82–1.13 | 0.7 |
| WBC, continuous | 1.06 | 0.89–1.22 | 0.5 | 1.00 | 0.86–1.14 | 0.9 |
| Plts, continuous | 0.91 | 0.87–1.11 | 0.2 | 0.97 | 0.90–1.17 | 0.3 |
Abbreviations: ALC: absolute lymphocyte count; ANC: absolute neutrophil count; AMC: absolute monocyte count; CR: complete remission; IPS: international prognostic score; PR: partial response; Plts: platelets; WBC: white blood cell count.