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. 2013 Apr 12;32(10):1478–1488. doi: 10.1038/emboj.2013.79

Figure 5.

Figure 5

Graphic depiction of glycosites in proteins by a novel GlycoDomainViewer. Representative examples of selected O-glycoproteins depicted based on the GlycoDomainViewer. O-GalNAc sites identified in SC are listed in the upper side of each protein while sites predicted by NetOGlyc4.0 are located on the lower half. N-glycan sites, experimentally verified as well as predicted, are obtained from UniProt. Designations are as follows: SP, signal peptide; TNFR, tumour necrosis factor receptor; TM, transmembrane; alpha_CA, carbonic anhydrase alpha; FN3, fibronectin type 3; HSP70, heat shock protein 70; MIR, domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases; Glyco_Hydro_47, Glycosyl hydrolase family 47; PG_binding_1, putative peptidoglycan-binding domain; ZnMc_MMP, zinc-dependent metalloprotease; Hemop, hemopexin; FZ.; frizzled; LDLa, low-density lipoprotein receptor domain class A; EGF, calcium-binding EGF domain; LY, low-density lipoprotein-receptor YWTD domain. The listed proteins are TNF1B (tumour necrosis factor receptor superfamily member 1B, P20333), PTPRG (receptor-type tyrosine-protein phosphatase gamma, P23470), GRP78 (78 kDa glucose-regulated protein, P11021), SDF2L (stromal cell-derived factor 2-like protein 1, Q9HCN8), MAN1C1 (Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC, Q9NR34), MMP15 (matrix metalloproteinase-15, P51511), FZD2 (frizzled-2, Q14332), LDLR (low-density lipoprotein receptor, P01130), and VLDLR (very low-density lipoprotein receptor, P98155).