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. 2013 Apr 19;32(10):1451–1468. doi: 10.1038/emboj.2013.87

Figure 1.

Figure 1

NAC prevents polyQ aggregation and is an important component of the cellular proteostasis network. (A) Depletion of NAC leads to a higher aggregation propensity of polyQ proteins. The aggregation propensity of the threshold polyQ model Q35-YFP expressed in muscle cells was analysed on day 4 upon knockdown of αNAC, βNAC and α+βNAC. The pictures show representative images of the head region. PolyQ aggregates are indicated by red triangles. The scale bars are 25 μm. (B) Quantification of the number of Q35 aggregates in the whole nematode. Error bars represent mean±s.d. of 50 animals.