Figure 8.

Model for reversible and age/chronic stress-dependent translational control by NAC. Acute proteotoxic challenges (left branch) lead to a temporary translational attenuation due to a sequestration of NAC by misfolded and aggregated proteins. Re-balancing of proteostasis liberates NAC and allows for re-association with ribosomes and translation resumes. Ageing and chronic stress conditions (right branch) lead to a permanent sequestration of NAC and hence to a decrease in protein synthesis.