Figure 2.
Ribbon diagram of the TbPTR1 subunit architecture and the position of the active site. The β6–loop–α6 segment is coloured red. The cofactor is depicted as blue sticks and the substrate, folate, as black sticks. The side chain of Trp221, on the edge of the active site, is shown as red sticks. Figs. 2 and 3 were derived using PDB entry 3bmc (Tulloch et al., 2010).