Figure 1.
Spontaneous GABAergic currents in Cajal-Retzius cells. A, Pharmacologically isolated GABAergic currents in visually identified Cajal-Retzius cells of the CXCR4–EGFP mouse hippocampus. Trace recorded at Vholding = −60 mV with chloride-loaded intracellular solution (P14). The inset shows an example of an EGFP-positive cell, showing the characteristic “tadpole” morphology of a Cajal-Retzius cell. B, Cumulative distribution plot of events recorded from an individual cell (P14): notice the large variability of the events. C, Summary plots obtained from n = 14 cells. Ionotropic glutamatergic transmission blocked throughout via NBQX (25 μm) and d-AP-5 (50 μm).