Table 2.
Univariate analysis contributing to OS and RFS for all cases (n = 233).
|
Variables |
n | OS | RFS |
|---|---|---|---|
| P valuea | P valuea | ||
| Age ≥ 70 (yes/no) | 125/108 | 0.096 | 0.779 |
| Gender (male/female) | 159/74 | 0.070 | 0.445 |
| HCC stages (I, II/III, and IV) | 163/70 | <0.001 | <0.001 |
| Maximum tumor size ≥ 3.5 cm (yes/no) | 116/117 | 0.016 | 0.071 |
| Tumor number (single/multiple) | 162/71 | 0.005 | <0.001 |
| IFN therapy after surgery (yes/no) | 16/217 | 0.039 | 0.019 |
| Body mass index ≥ 25 kg/m2 (yes/no) | 60/173 | 0.818 | 0.124 |
| Diabetes mellitus (yes/no) | 64/169 | 0.311 | 0.994 |
| ICGR 15 ≥ 13.5% (yes/no) | 115/118 | 0.038 | 0.402 |
| Total bilirubin ≥ 0.8 mg/dL (yes/no) | 115/118 | 0.142 | 0.487 |
| Serum albumin ≥ 3.8 g/dL (yes/no) | 128/105 | <0.001 | 0.088 |
| AST ≥ 60 IU/L (yes/no) | 110/123 | 0.090 | 0.042 |
| ALT ≥ 50 IU/L (yes/no) | 113/120 | 0.261 | 0.014 |
| Platelets ≥ 12 × 104/mm3 (yes/no) | 128/105 | 0.065 | 0.679 |
| Prothrombin time ≥ 87% (yes/no) | 122/111 | 0.236 | 0.067 |
| AFP ≥ 20 ng/mL (yes/no) | 122/111 | <0.001 | 0.010 |
| DCP ≥ 100 mAU/mL (yes/no) | 135/98 | 0.144 | 0.031 |
| Total cholesterol ≥ 160 IU/L (yes/no) | 109/124 | 0.476 | 0.575 |
| Microscopic capsule (yes/no) | 185/48 | 0.630 | 0.551 |
| Microscopic capsule invasion (yes/no) | 140/93 | 0.215 | 0.467 |
| Microscopic vascular invasion (yes/no) | 73/160 | <0.001 | <0.001 |
| Microscopic surgical margin (yes/no) | 30/203 | 0.642 | 0.112 |
OS: overall survival, RFS: recurrence-free survival, HCC: hepatocellular carcinoma, IFN: interferon, ICGR 15: indocyanine green retention at 15 min, AST: aspartate aminotransferase, ALT: alanine aminotransferase, AFP: alpha-fetoprotein, DCP: des-γ-carboxy prothrombin, and alog-rank test.