Table 3.
Multivariate analysis associated with OS after surgical resection for hepatocellular carcinoma.
| Variable | Hazard ratio | 95% confidence interval | P valuea |
|---|---|---|---|
| HCC stage | |||
| Stage I or II | 1.000 | 0.069 | |
| Stage III or IV | 0.423 | 0.168–1.070 | |
| Maximum tumor size | |||
| ≥3.5 cm | 0.765 | 0.502–1.167 | 0.214 |
| <3.5 cm | 1.000 | ||
| Tumor number | |||
| Single | 1.299 | 0.520–3.244 | 0.576 |
| Multiple | 1.000 | ||
| IFN therapy after surgery | |||
| Yes | 3.054 | 0.745–12.520 | 0.121 |
| No | 1.000 | ||
| ICGR 15 | |||
| ≥13.5% | 0.954 | 0.623–1.460 | 0.828 |
| <13.5% | 1.000 | ||
| Serum albumin level | |||
| ≥3.8 g/dL | 1.981 | 1.295–3.031 | 0.002 |
| <3.8 g/dL | 1.000 | ||
| AFP level | |||
| ≥20 ng/mL | 0.425 | 0.274–0.660 | <0.001 |
| <20 ng/mL | 1.000 | ||
| Microscopic vascular invasion | |||
| Yes | 0.549 | 0.359–0.840 | 0.006 |
| No | 1.000 |
OS: overall survival, HCC: hepatocellular carcinoma, IFN: interferon, ICGR 15: indocyanine green retention at 15 min, AFP: alpha-fetoprotein, and aThe Cox proportional hazard model.