Table 1.
Mutations associated with resistance to clarithromycin and fluoroquinolone.
| Mutant strain |
Number of independent mutations analysed |
Mutant allelesa | ||
|---|---|---|---|---|
| Designation | Amino acid change | MIC (µg/mL) | ||
| 245A | 1 | 23SMUT3 | A2147G | 256 |
| 245C | 1 | 23SMUT3 | A2147G | 32 |
| 247A | 2 |
23SMUT3
No gyr 87 WT |
A2147G N87K |
256 |
| 247C | 1 | No gyr 87 WT | N87K | 8 |
| 249A | 1 | No gyr 87 WT | N87K | 32 |
| 249C | 1 | No gyr 87 WT | N87K | 16 |
| 252A | 2 | No gyr 87 WT 23SMUT3 |
N87K A2147G |
32 |
| 252C | 4 | No gyr 87 WT gyr 91 WT 23SMUT2 23SMUT3 |
N87K D91N A2146C A2147G |
32 |
| 253C | 1 | No gyr 87 WT | N87K | 16 |
| 254A | 1 | 23SMUT3 | A2147G | 256 |
| 119A | 1 | 23SMUT3 | A2147G | 32 |
| 275A | 1 | 23SMUT3 | A2147G | 128 |
| 305A | 1 | 23SMUT3 | A2147G | 64 |
| 305C | 1 | 23SMUT3 | A2147G | 128 |
| 369A | 1 | No gyr 87 WT | N87K | 16 |
| 436C | 1 | 23SMUT3 | A2147G | 256 |
| 499C | 1 | 23SMUT3 | A2147G | 64 |
aDistinct mutation identified is given an allele name (designation), which represents a specific change at the nucleotide (nt) in a gene and a corresponding amino acid change in the gene product.