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. 2013 Apr 24;2013:498925. doi: 10.1155/2013/498925

Figure 2.

Figure 2

Altered serum cytokines and serum lipids in KK-A y mice. (a) Leptin levels were elevated in KK-A y (versus KK-a/a control). Addition of uninephrectomy (Unx) elevated serum leptin, both in KK-a/a and in KK-A y mice (P < 0.01). (b) A similar profile was observed for serum triglycerides, which were elevated in KK-A y (versus KK-a/a control). As with leptin, Unx further elevated triglycerides both in KK-a/a and in KK-A y mice (P < 0.01). (c) Relative to KK-a/a controls, KK-a/a + Unx, KK-A y, and KK-A y + Unx mice all showed markedly elevated serum cholesterol (P < 0.001). (d) Serum PAI-1 levels were elevated in KK-A y mice compared to age-matched KK-a/a animals (P < 0.01). However, PAI-1 levels in KK-A y were unaffected by Unx.