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. 2013 Apr 24;2013:498925. doi: 10.1155/2013/498925

Figure 4.

Figure 4

Decreased renal function in KK-A y is exacerbated by uninephrectomy. (a) Compared to KK-a/a mice, blood urea nitrogen (BUN) is slightly elevated in KK-A y and KK-a/a + Unx, though this difference is not statistically significant at later time points in the KK-a/a + Unx group. Uninephrectomy further elevates BUN in KK-A y, with BUN increased by twofold, indicating mild uremia in KK-A y + Unx animals. (b) Renal function, as measured by glomerular filtration rate (GFR), is reduced by 32% in KK-A y + Unx mice compared to KK-a/a littermate controls (P < 0.001).