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The interindividual differences in the extent of changes in the AUC and CL of MDZ by baicalin. The changes in the AUC0–∞ ((a), (c)) and CL ((b), (d)) of MDZ (10 mg/kg, i.v.) in rats after treatment with baicalin at a single dose of 0.225 g/kg (n = 8) or 0.45 g/kg (n = 9) or at a dose of 0.90 g/kg once for 1 day and the same dose for 7 days (n = 8).
