Table 1.
Pharmacokinetic parameters of baicalin after intravenous administration in rats.
| Baicalin (0.225 g/kg) | Baicalin (0.45 g/kg) | Baicalin (0.90 g/kg) | ||
|---|---|---|---|---|
| Single | Multiplea | |||
| C max (mg/L) | 879 ± 150 | 1630 ± 212 | 3070 ± 350 | 3030 ± 314 |
| t 1/2 (h) | 0.34 ± 0.06 | 0.32 ± 0.04 | 0.49 ± 0.13 | 0.42 ± 0.13 |
| V (L/kg) | 0.36 ± 0.12 | 0.16 ± 0.05 | 0.45 ± 0.10 | 0.39 ± 0.10 |
| CL (L/h/kg) | 0.72 ± 0.15 | 0.34 ± 0.07 | 0.65 ± 0.14 | 0.66 ± 0.16 |
| AUC0–t (mg·h/L) | 320 ± 66 | 673 ± 123 | 1342 ± 230 | 1374 ± 308 |
| AUC0–∞ (mg·h/L) | 325 ± 67 | 683 ± 121 | 1438 ± 286 | 1441 ± 332 |
aOnce daily for 7 days. Rats received intravenous administration of baicalin at a single dose of 0.225 or 0.45 g/kg (n = 9) or at a dose of 0.90 g/kg once for 1 day and the same dose for 7 days (n = 8). The results were means ± SD of the indicated number of rats.