Table 2.
Pharmacokinetic parameters of MDZ (10 mg/kg, i.v.) after treatment with a single dose of baicalin (0.225, 0.45 g/kg, i.v.) in rats.
| Control | Baicalin (0.225 g/kg) | Baicalin (0.45 g/kg) | |||
|---|---|---|---|---|---|
| Value | Value | Ratio | Value | Ratio | |
| C max (mg/L) | 6.5 ± 1.0 | 7.0 ± 1.4 | 1.10 (0.94 ~ 1.26) | 7.3 ± 1.9 | 1.15 (0.89 ~ 1.41) |
| t 1/2 (h) | 0.44 ± 0.08 | 0.51 ± 0.18 | 0.51 ± 0.16 | ||
| V (L/kg) | 3.6 ± 0.7 | 3.0 ± 1.0 | 3.1 ± 1.4 | ||
| CL (L/h/kg) | 5.9 ± 0.9 | 4.3 ± 0.9* | 0.75 (0.58 ~ 0.92) | 4.2 ± 0.8** | 0.72 (0.58 ~ 0.87) |
| AUC0–t (mg·h/L) | 1.7 ± 0.2 | 2.3 ± 0.7* | 1.42 (1.01 ~ 1.84) | 2.4 ± 0.6* | 1.44 (1.12 ~ 1.75) |
| AUC0–∞ (mg·h/L) | 1.7 ± 0.2 | 2.5 ± 0.8* | 1.47 (1.00 ~ 1.94) | 2.5 ± 0.6** | 1.47 (1.15 ~ 1.79) |
The results are means ± SD of 8-9 rats. Ratios are expressed as geometric mean ratio with 90% CI. Significance is indicated as *P < 0.05; **P < 0.01 compared to the control.