Table 3.
Pharmacokinetic parameters of MDZ (10 mg/kg, i.v.) after treatment with baicalin.
| Control | Baicalin (0.90 g/kg, 1 day) | Baicalin (0.90 g/kg, 7 days) | |||
|---|---|---|---|---|---|
| Value | Value | Ratio | Value | Ratio | |
| C max (mg/L) | 6.3 ± 1.3 | 7.0 ± 1.2 | 1.13 (0.92 ~ 1.34) | 7.8 ± 0.9* | 1.27 (1.03 ~ 1.51) |
| t 1/2 (h) | 0.40 ± 0.10 | 0.47 ± 0.11 | 0.44 ± 0.10 | ||
| V (L/kg) | 3.2 ± 0.9 | 2.5 ± 0.5 | 1.9 ± 0.4** | ||
| CL (L/h/kg) | 5.6 ± 0.7 | 3.7 ± 0.6*** | 0.66 (0.58 ~ 0.74) | 3.2 ± 0.8*** | 0.57 (0.43 ~ 0.71) |
| AUC0–t (mg·h/L) | 1.7 ± 0.2 | 2.6 ± 0.4** | 1.50 (1.34 ~ 1.67) | 3.2 ± 0.8** | 1.86 (1.48 ~ 2.24) |
| AUC0–∞ (mg·h/L) | 1.8 ± 0.2 | 2.8 ± 0.5** | 1.53 (1.34 ~ 1.73) | 3.4 ± 0.9** | 1.87 (1.47 ~ 2.28) |
Rats received intravenous administration of baicalin at a dose of 0.90 g/kg once for 1 day and the same dose for 7 days. The results are means ± SD of 8 rats. Ratios are expressed as geometric mean ratio with 90% CI. Significance is indicated as *P < 0.05; **P < 0.01; ***P < 0.001 compared to the control.