Table 4.

Effects of multiple doses of baicalin on MDZ hydroxylation activity in the rat liver.

	Group	V max⁡ (nmol/min/mgprotein)	K m (μM)	CLint⁡ (μL/min/mg protein)
1′-Hydroxymidazolam	Control	0.528 ± 0.061	18.6 ± 2.4	28.4 ± 1.5
	Baicalin	0.388 ± 0.075**	18.2 ± 5.0	21.8 ± 3.1***
4-Hydroxymidazolam	Control	1.188 ± 0.227	15.4 ± 3.6	77.9 ± 9.3
	Baicalin	0.849 ± 0.143**	14.2 ± 4.0	61.7 ± 11.1**

Rats received intravenous administration of baicalin at a dose of 0.90 g/kg once daily for 7 days. The results are means ± SD of 8 rats. Significance is indicated as **P < 0.01, ***P < 0.001 compared to the control.