Table 4.
EC50 values and potency (pEC50) of CF-AECal-induced relaxation of rat tracheal smooth muscle contracted by 10 µM acetylcholine under various experimental conditions.
| Treatment groups | EC50 (mg/mL) | pEC50 |
|---|---|---|
| Control | 0.021 (0.013–0.031) | 1.68 ± 0.08 |
| L-NAME (100 µM) | 0.018 (0.010–0.031) | 1.4 ± 0.09 |
| Indomethacin (10 µM) | 0.019 (0.011–0.031) | 1.73 ± 0.11 |
| Methylene blue (100 µM) | 0.021 (0.008–0.054) | 1.68 ± 0.15 |
| Propranolol (1 µM) | 0.029 (0.010–0.081) | 1.54 ± 0.16 |
| TEA (5 mM) | 0.184 (0.123–0.274) | 0.74 ± 0.08*** |
| Glibenclamide (10 µM) | 0.022 (0.015–0.032) | 1.65 ± 0.07 |
EC50 was obtained from the concentration-response curve of CF-AECal. Data are expressed as the mean ± SEM of 6–8 experiments. Significantly different from control: *P < 0.05, **P < 0.01, and ***P < 0.001.