FIG. 5.

Antitumor effect of MeV ld-SCD+prodrug 5-FC in a HuCCT1 human CC xenograft mouse model. HuCCT1 CC cells (1×10⁷ in 100 μl PBS) were injected subcutaneously into the right flank of female nude mice. When tumors reached a volume of about 100 mm³, mice were randomized into four treatment groups: control (12 mice), control+prodrug 5-FC (5 mice), MeV ld-SCD only (12 mice), and MeV ld-SCD+prodrug 5-FC (12 mice). Mice were treated daily with intratumoral injections of MeV ld-SCD (2×10⁶ pfu per dose) or vehicle control (days 0–4), followed by seven intraperitoneal injections of 5-FC (500 mg/kg body weight; days 5–11). (A) Mean tumor volume for each group. (B) Individual tumor volumes at day 48 (n.s., not significant). (C) Kaplan–Meier survival analysis for the individual treatment groups.