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Use of alternative splicing gives rise to p63 isoforms of 2 subclasses: TAp63 and ΔNp63. Within each of these subclasses, C-terminal alternative splicing gives rise to α, β, γ, δ, and ε isoforms. The isoforms share homology in certain protein domains: TA (transactivation domain), ΔN, DBD (DNA binding domain), OD (oligomerization domain), SAM (sterile alpha motif domain), and TID (transactivation inhibition domain).
