Table 1.
Numerical density and cellular composition of BCG granulomas in the liver and lungs of BCG-infected mice.
| Parameter | Liver | Lungs | ||||
|---|---|---|---|---|---|---|
| Time after infection (days) | ||||||
| 30 | 60 | 90 | 30 | 60 | 90 | |
| Numerical density of granulomas (Nai), 3.64 × 105 μm2 | 3.08 ± 0.26 | 7.84 ± 0.64# | 8.36 ± 0.54 | 7.40 ± 0.57 | 8.24 ± 0.51 | 11.24 ± 0.46# |
| Diameter of granulomas, μm | 47.25 ± 1.26 | 53.18 ± 1.54# | 58.92 ± 1.32# | 49.69 ± 1.24 | 68.71 ± 0.34# | 71.12 ± 1.82 |
| Macrophage number, %$ | 65.12 ± 0.69 | 33.85 ± 0.87# | 14.72 ± 1.33# | 47.94 ± 0.53 | 27.11 ± 0.86# | 23.13 ± 0.59# |
| Epithelioid cell number, %$ | 22.56 ± 0.87 | 57.05 ± 0.89# | 77.35 ± 1.42# | 26.37 ± 0.23 | 52.21 ± 1.04# | 58.21 ± 0.23# |
| Neutrophil number, %$ | 2.47 ± 0.18 | 0.69 ± 0.14# | 0.21 ± 0.09# | 1.83 ± 0.23 | 2.53 ± 0.49 | 2.09 ± 0.42 |
| Lymphocyte number, %$ | 7.51 ± 0.30 | 5.47 ± 0.20# | 1.64 ± 0.27# | 12.48 ± 1.21 | 7.19 ± 0.36# | 3.92 ± 0.31# |
| Fibroblast number, %$ | 2.34 ± 0.20 | 2.94 ± 0.18# | 6.08 ± 0.24# | 11.38 ± 0.31 | 10.96 ± 0.36 | 12.65 ± 0.81# |
The results represent the mean ± SEM.
$100%: the total number of cells in granuloma. #The value significantly differs from the value for the previous observation period (P < 0.05).