Table 2.
Incidence rate ratios (RR) and 95% confidence intervals (CI) for the association between self-reported ABO blood type and incidence of breast cancer among 67,697 women in the Nurses’ Health Study
| ABO blood type
|
|||||
|---|---|---|---|---|---|
| O | A | AB | B | Non-O (A, AB or B) | |
| Person-years | 266,049 | 219,622 | 48,298 | 83,264 | 351,184 |
| All cancers (invasive + in situ) | |||||
| Cases | 1,284 | 1,136 | 252 | 435 | 1,823 |
| RR (95% CI)* | 1.00 (ref) | 1.06 (0.98, 1.15) | 1.06 (0.93, 1.22) | 1.08 (0.96, 1.20) | 1.07 (0.99, 1.15) |
| Invasive cancers | |||||
| Cases | 1,040 | 912 | 212 | 348 | 1,472 |
| RR (95% CI)* | 1.00 (ref) | 1.06 (0.97, 1.15) | 1.10 (0.95, 1.28) | 1.06 (0.94, 1.20) | 1.06 (0.98, 1.15) |
| Ductal cancers | |||||
| Cases | 792 | 681 | 146 | 258 | 1,085 |
| RR (95% CI)* | 1.00 (ref) | 1.04 (0.93, 1.15) | 1.00 (0.84, 1.20) | 1.03 (0.90, 1.19) | 1.03 (0.94, 1.13) |
| Lobular cancers | |||||
| Cases | 121 | 100 | 28 | 51 | 179 |
| RR (95% CI)* | 1.00 (ref) | 1.00 (0.77, 1.31) | 1.23 (0.81, 1.85) | 1.35 (0.97, 1.87) | 1.12 (0.89, 1.41) |
| ER positive/PR positive | |||||
| Cases | 614 | 521 | 119 | 212 | 852 |
| RR (95% CI)* | 1.00 (ref) | 1.02 (0.91, 1.15) | 1.06 (0.87, 1.29) | 1.10 (0.94, 1.28) | 1.05 (0.94, 1.16) |
| ER positive/PR negative | |||||
| Cases | 144 | 113 | 26 | 56 | 195 |
| RR (95% CI)* | 1.00 (ref) | 0.95 (0.74, 1.22) | 0.96 (0.63, 1.46) | 1.26 (0.92, 1.71) | 1.02 (0.82, 1.27) |
| ER negative/PR negative | |||||
| Cases | 131 | 140 | 30 | 32 | 202 |
| RR (95% CI)* | 1.00 (ref) | 1.28 (1.00, 1.62) | 1.22 (0.82, 1.82) | 0.77 (0.52, 1.13) | 1.15 (0.92, 1.43) |
| HER2/neu positive cancers | |||||
| Cases | 111 | 105 | 27 | 37 | 169 |
| RR (95% CI)* | 1.00 (ref) | 1.13 (0.86, 1.47) | 1.32 (0.87, 2.02) | 1.09 (0.75, 1.58) | 1.14 (0.90, 1.46) |
*
Adjusted for age in months only; no evidence of confounding by any other covariate examined