Table 1.
Basal dialysate dopamine concentrations and peak dialysate ethanol concentrations in MOR +/+, −/− and +/− male (M) and female (F) C57BL/6J mice. Values represent mean concentrations ± SEM.
Experiment | Sex | Genotype | Basal DA (nM) | Peak EtOH (mM) | n |
---|---|---|---|---|---|
| |||||
1g/kg | M | +/+ | 1.2 ± 0.1 | 4.1 ± 0.8 | 5 |
−/− | 1.1 ± 0.3 | 4.9 ± 0.6 | 3 | ||
+/− | 1.4 ± 0.2 | 4.7 ± 0.6 | 6 | ||
| |||||
F | +/+ | 1.4 ± 0.1 | 5.4 ± 0.4 | 5 | |
−/− | 1.6 ± 0.4 | 5.0 ± 0.6 | 6 | ||
+/− | 1.5 ± 0.2 | 4.5 ± 0.4 | 6 | ||
| |||||
2g/kg | M | +/+ | 1.2 ± 0.4 | 11.1 ± 1.1 | 6 |
−/− | 1.6 ± 0.5 | 10.5 ± 1.5 | 5 | ||
+/− | 1.3 ± 0.2 | 10.4 ± 0.8 | 7 | ||
| |||||
F | +/+ | 1.2 ± 0.4 | 10.5 ± 0.3 | 5 | |
−/− | 1.2 ± 0.3 | 10.9 ± 1.1 | 6 | ||
+/− | 1.3 ± 0.2 | 9.5 ± 0.8 | 6 | ||
| |||||
3g/kg | M | +/+ | 1.1 ± 0.3 | 14.6 ± 1.0 | 5 |
−/− | 1.4 ± 0.5 | 14.7 ± 1.3 | 4 | ||
+/− | 1.5 ± 0.3 | 14.6 ± 0.5 | 8 | ||
| |||||
F | +/+ | 1.1 ± 0.3 | 14.9 ± 0.8 | 6 | |
−/− | 1.3 ± 0.3 | 13.7 ± 1.4 | 8 | ||
+/− | 1.2 ± 0.3 | 16.7 ± 1.9 | 7 | ||
| |||||
Morphine | +/+ | 1.2 ± 0.3 | — | 9 | |
— | (5M, 4F) | ||||
| |||||
−/− | 0.9 ± 0.2 | — | 7 | ||
— | (5M, 2F) |