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. Author manuscript; available in PMC: 2013 May 16.
Published in final edited form as: Nat Neurosci. 2012 Oct 7;15(11):10.1038/nn.3236. doi: 10.1038/nn.3236

Figure 6. Temporal relationship of MECIII persistent Up states and CA1 activity.

Figure 6

a) The influence of MECIII (orange trace) and neocortical (brown trace) Up transitions on CA1 MUA are plotted as a function of relative time lag. b) Data are presented as in a for the Down transitions. CA1 MUA was much more strongly modulated by MECIII compared to neocortical state transitions. c) Neocortical Down transition triggered average MECIII membrane potential (red trace), neocortical LFP (gray trace), and CA1 MUA (violet trace) are plotted, using only neocortical Down transitions which were not skipped by MECIII persistent Up states. Note the separate y-axis for CA1 MUA rate (green, right). d) Data are presented as in c, using only neocortical Down transitions which were skipped by MECIII persistent Up states. e) Average CA1 MUA rates during persistent MECIII Up states (0.41 ± 0.071 Hz) were significantly higher than during non-persistent MECIII Up states (0.21 ± 0.047 Hz; p=6.7×10−3). The solid black line shows the diagonal. f) The strength of neocortical UDS modulation of CA1 MUA during persistent MECIII Up states is plotted against the corresponding modulation strength taken over all times. Neocortical UDS modulation of CA1 MUA was significantly more negative (−0.36 ± 0.093 z) during MECIII persistent Up states compared to overall (−0.16 ± 0.066 z; p=1.7×10−3).