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. Author manuscript; available in PMC: 2013 May 16.
Published in final edited form as: Nat Neurosci. 2012 Oct 7;15(11):10.1038/nn.3236. doi: 10.1038/nn.3236

Figure 7. Stochastic mechanism for MECIII persistent Up states and their influence on cortico-entorhinal-hippocampal responses during UDS oscillations.

Figure 7

a) Scatterplot showing the relationship between the percentage of a neuron’s Up states which are persistent and its “relative” Down transition lag, as a fraction of the corresponding neocortical Down state duration. These quantities were significantly correlated for both the MECIII neurons (r=0.45, p=3.5×10−3) and the LECIII neurons (r=0.76, p=2.4×10−3). Inset at right shows a magnification of the region indicated by the black box at left. b) A sequence of Up and Down states are illustrated for neocortex (black trace), LECIII (blue trace), and MECIII (red trace). Two possible MECIII and CA1 state sequences are illustrated by the solid and dashed red and violet traces, with the solid line depicting a persistent MECIII Up state. The duration of the entorhinal Down transition lag determines the probability of skipping a down state and generating a persistent state (red arrow) via a stochastic mechanism. The green trace illustrates the spiking activity of CA1 pyramidal neurons. Neocortical state transition times are indicated by the black vertical dashed lines. Note that CA1 activity is highest when the neocortex is in a Down state and MECIII neurons are in a persistent Up state.