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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Mamm Genome. 2012 Aug 29;23(0):587–599. doi: 10.1007/s00335-012-9430-2

Table 2. Large-scale Cre-Driver Projects.

Projects Approaches Cre-Drivers planned/produced Availability
AIBS Cre (http://connectivity.brain-map.org/)

  • Small-Insert-Random Insertion 5′ Knock-in at Endogenous Locus

  • 3′ Knock-in at Endogenous Locus

 17 JAX
CanEuCre (http://www.caneucre.org/)

  • Small-Insert Knock-in at Docking Site (5′ of Hprt)

  • Large-Insert Knock-in at Docking Site (5′ of Hprt)

 30 planned/8 produced so far TBD
EUCOMMTOOLS (http://www.knockoutmouse.org/about/eucommtools)

  • Large-Insert knock-in at Docking Site (Hprt)

  • 3′ Knock-in at Endogenous Locus

 250 strains/500 ES lines EMMA
GENSAT (http://www.gensat.org/CrePipeline.jsp)

  • Large-Insert-Random Insertion (BAC)

 256/124 available MMRRC
Neuroscience Blueprint Cre (www.credrivermice.org)

  • Small-Insert-Random Insertion

  • 5′ Knock-in at EndogenousLocus

  • Enhancer trap

 95 MMRRC JAX
NorCOMM2ls

  • Transposon-based enhancer trap

 50 planned CMMR
ICS Cre Zoo (http://www.ics-mci.fr/mousecre/)

  • Large-Insert-Random Insertion (BAC)

  • 5′ Knock-in at endogenous locus

  • Small-Insert-Random Insertion

 50 produced ICS
FaceBase Cre (www.facebase.org)

  • Large-Insert-Random Insertion (BAC)

  • 3′ Knock-in at Endogenous Locus

  • Enhancer Knock-in at Docking Site

 15 planned JAX
Pleiades (http://pleiades.org/)

  • Small-Insert Knock-in at Docking Site (5′ of Hprt)

 6 planned/6 produced JAX

TBD, to be determined