Table 2.
Univariable and multivariable associations with mortality up to 3 years on cART
| Mortality per 100 PYRs |
HR | p | aHR | p | |
|---|---|---|---|---|---|
| Sex | |||||
| Men | 5.1 (4.8, 5.4) | Referent | <0.001 | Referent | 0.009 |
| Women | 3.4 (3.2, 3.5) | 0.75 (0.69, 0.81) | 0.89 (0.82, 0.97) | ||
|
| |||||
| Age (years) | |||||
| 16-24 | 3.3 (2.8, 3.9) | Referent | <0.001 | Referent | <0.001 |
| 25-34 | 3.3 (3.1, 3.5) | 0.96 (0.80, 1.15) | 1.02 (0.85, 1.22) | ||
| 35-44 | 4.3 (4.0, 4.6) | 1.16 (0.97, 1.39) | 1.26 (1.05, 1.52) | ||
| >44 | 5.4 (5.0, 5.8) | 1.43 (1.18, 1.72) | 1.58 (1.30, 1.91) | ||
| Weight at ART initiation (kg) | |||||
| <50 | 7.1 (6.6, 7.7) | Referent | Referent | ||
| 50-80 | 3.7 (3.5, 3.8) | 0.52 (0.48, 0.57) | 0.55 (0.50, 0.61) | ||
| >80 | 2.9 (2.5, 3.4) | 0.37 (0.30, 0.46) | 0.46 (0.38, 0.57) | ||
|
| |||||
| Current CD4 count (cells/mm3) | |||||
| ≤100 | 14 (14, 15) | Referent | <0.001 | Referent | <0.001 |
| 100-200 | 5.0 (4.7, 5.4) | 0.32 (0.29, 0.35) | 0.38 (0.32, 0.46) | ||
| 201-350 | 2.5 (2.3, 2.8) | 0.15 (0.14, 0.17) | 0.18 (0.13, 0.25) | ||
| >350 | 1.4 (1.2, 1.6) | 0.09 (0.07, 0.10) | 0.10 (0.05, 0.20) | ||
|
| |||||
| CD4 count trend* | <0.001 | <0.001 | |||
| CD4 count: <100 | |||||
| >25% decrease | 30 (27, 33) | Referent | Referent | ||
| no change | 20 (17, 23) | 0.66 (0.56, 0.79) | 0.75 (0.63, 0.89) | ||
| >25% increase | 16 (14, 18) | 0.52 (0.45, 0.60) | 0.68 (0.58, 0.79) | ||
| CD4 count: 100-200 | |||||
| >25% decrease | 8.2 (6.9, 9.7) | Referent | Referent | ||
| no change | 5.2 (4.4, 6.0) | 0.70 (0.57, 0.86) | 0.79 (0.64, 0.98) | ||
| >25% increase | 4.3 (3.7, 5.0) | 0.65 (0.53, 0.80) | 0.79 (0.63, 0.98) | ||
| CD4 count: 201-350 | |||||
| >25% decrease | 2.4 (1.8, 3.4) | Referent | Referent | ||
| no change | 2.1 (1.8, 2.5) | 0.79 (0.56, 1.09) | 0.87 (0.63, 1.21) | ||
| >25% increase | 2.8 (2.5, 3.2) | 1.00 (0.71, 1.43) | 1.11 (0.78, 1.58) | ||
| CD4 count: >350 | |||||
| >25% decrease | 0.91 (0.46, 2.0) | Referent | Referent | ||
| no change | 1.0 (0.83, 1.3) | 0.88 (0.41, 1.88) | 0.95 (0.45, 2.03) | ||
| >25% increase | 1.6 (1.3, 1.8) | 1.25 (0.60, 2.62) | 1.31 (0.63, 2.76) | ||
|
| |||||
| HIV RNA (c/mL) | |||||
| <400 | 2.8 (2.7, 3.0) | Referent | <0.001 | Referent | <0.001 |
| 400-4999 | 3.6 (3.3, 4.0) | 1.95 (1.69, 2.26) | 1.63 (1.41, 1.89) | ||
| 5000-50,000 | 9.7 (8.8, 11) | 3.34 (2.94, 3.80) | 2.18 (1.92, 2.48) | ||
| >50,000 | 22 (20, 23) | 6.51 (5.89, 7.20) | 3.16 (2.82, 3.55) | ||
HR, crude hazard ratio; aHR, adjusted hazard ratio
*
interaction between updated CD4 count and CD4 count slope; p<0.001