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. Author manuscript; available in PMC: 2013 May 16.
Published in final edited form as: Acta Pharm Sin B. 2012 Apr 1;2(2):213–219. doi: 10.1016/j.apsb.2012.02.008

Table 1.

In vitro metabolic stability profiles of prodrugs together with the parent drug in SD rat liver microsomes.

Parameter Compound
3 5 6 7 8 9 10 11 12 13 PROa
k obs 0.039 0.020 0.020 0.024 0.027 0.178 0.014 0.023 0.023 0.026 0.033
T1/2 (min) 17.92 34.61 35.27 29.07 25.93 3.90 49.26 30.09 30.77 26.54 20.71
CLint (mL/min/mg) 0.39 0.20 0.20 0.24 0.27 1.78 0.14 0.23 0.23 0.26 0.33
a

Reference compounds: propranolol (moderate metabolism in vivo with T1/2 of 3–5 h).