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. Author manuscript; available in PMC: 2013 May 16.
Published in final edited form as: Nat Neurosci. 2011 Oct 26;14(11):1382–1389. doi: 10.1038/nn.2963

Figure 2.

Figure 2

Perivascular interactions with the adult mammalian subependyma. This cartoon illustrates the architecture of the striatal ventricular wall and shows the relationships of subependymal NSCs (B cells, according to the nomenclature of Alvarez-Buylla3,19,75) to transit-amplifying progeny (C cells) and their neuronally restricted progeny (A cells). Major molecular interactions, as citevd in the text, include the provision of ATP to vascular NTPDase-2/CD39L1, with generation of ADP that interacts with B and C cell P2YRs, vascular VEGF and PEDF, which interact with cognate B cell receptors, B cell CD15 and C and A cell CD24 with their endothelial P-selectin receptors, endothelial SDF1/CXCL12 with its A cell receptors CXCR4 and CXCR7, endothelial BDNF with both its B and C cell p75 and A cell trkB receptors, endothelial laminin with its C and A cell α6β1 integrin receptor, and both endothelial eNOS and neural precursor-derived nNOS, and their derived NO with cellular targets thereof.