Table 2.
Primary information for 7 genotyped SNPs in DNA repair genes
| Genotyped SNPs | Location/or amino acid change | MAF for Chinese in databasea | Pvalue for HWE test |
|---|---|---|---|
|
XRCC3: rs861539 C>T |
nsSNP/ T241M |
0.067 |
0.165 |
|
XRCC3: rs1799794 G>A |
5' UTR |
0.478 |
0.271 |
|
XRCC3: rs1799796 A>T |
nsSNP/ A17893G |
0.289 |
0.406 |
|
BRCA2: rs1799943 G>A |
Promoter |
0.279 |
0.722 |
|
BRCA2: rs15869 A>C |
3' UTR |
0.244 |
0.375 |
|
RAG1: rs2227973 G>A |
nsSNP/ R820K |
0.465 |
0.586 |
|
XRCC5: rs1051685 A>G |
3' UTR |
0.067 |
0.808 |
|
LIG4: rs1805388 C>T |
nsSNP/T9I |
0.261 |
0.659 |
|
XRCC4: rs1805377 A>G |
Splice Site |
0.300 |
0.454 |
| ATM: rs189037 G>A | Promoter | 0.389 | 0.070 |
MAF, minor allele frequency; HWE, Hardy-Weinberg equilibrium.
aMinor allele frequency in the Chinese (CHB, Han Chinese in Beijing, China) population, as reported in dbSNP database.