Table 3.
Associations between candidate genes and glioma risk
| Genotype | Cases, n(%) | Controls, n(%) | OR (95% CI)a | Ptrendb | Pvalue for HWE test |
|---|---|---|---|---|---|
|
XRCC3: rs861539 (T241M) | |||||
| CC |
336 (87.5) |
340 (88.5) |
1.00 |
0.835 |
0.165 |
| CT |
47 (12.2) |
41 (10.7) |
1.15 (0.73-1.79) |
|
|
| TT |
1 (0.3) |
3 (0.8) |
0.33 (0.03-3.22) |
|
|
|
XRCC3: rs1799794 (−4541G>A) | |||||
| GG |
100 (26.0) |
108 (28.1) |
1.00 |
0.838 |
0.271 |
| GA |
201 (52.4) |
181 (47.1) |
1.09 (0.78-1.53) |
|
|
| AA |
83 (21.6) |
95 (24.8) |
0.86 (0.57-1.28) |
|
|
|
XRCC3: rs1799796 (A17893G) | |||||
| AA |
178 (46.4) |
171 (44.5) |
1.00 |
0.231 |
0.406 |
| AT |
173 (45.0) |
165 (43.0) |
0.97 (0.72-1.31) |
|
|
| TT |
33 (8.6) |
48 (12.5) |
0.64 (0.39-1.04) |
|
|
|
BRCA2: rs1799943 (−26G>A) | |||||
| GG |
158 (41.2) |
180 (46.9) |
1.00 |
0.149 |
0.722 |
| GA |
186 (48.4) |
168 (43.7) |
1.22 (0.90-1.64) |
|
|
| AA |
40 (10.4) |
36 (9.4) |
1.22 (0.74-2.01) |
|
|
|
BRCA2: rs15869 (3' UTR) | |||||
| AA |
213 (55.5) |
220 (57.3) |
1.00 |
0.646 |
0.375 |
| AC |
143 (37.2) |
137 (35.7) |
1.05 (0.78-1.42) |
|
|
| CC |
28 (7.3) |
27 (7.0) |
1.04 (0.59-1.83) |
|
|
|
RAG1: rs2227973 (R820K) | |||||
| GG |
129 (33.6) |
134 (34.9) |
1.00 |
1.000 |
0.586 |
| GA |
200 (52.1) |
190 (49.5) |
0.96 (0.70-1.30) |
|
|
| AA |
55 (14.3) |
60 (15.6) |
0.83 (0.54-1.29) |
|
|
|
XRCC5: rs1051685 (3' UTR) | |||||
| AA |
313 (81.5) |
326 (84.9) |
1.00 |
0.232 |
0.808 |
| AG |
69 (18.0) |
56 (14.6) |
1.24 (0.84-1.82) |
|
|
| GG |
2 (0.5) |
2 (0.5) |
1.00 (0.37-2.68) |
|
|
|
LIG4: rs1805388 (T9I) | |||||
| CC |
163 (42.4) |
222 (57.8) |
1.00 |
< 0.001 |
0.659 |
| CT |
172 (44.8) |
142 (37.0) |
1.62 (1.20-2.18) |
|
|
| TT |
49 (12.8) |
20 (5.2) |
3.27 (1.87-5.71) |
|
|
|
XRCC4: rs1805377 (Splice Site) | |||||
| AA |
179 (46.6) |
195 (50.8) |
1.00 |
0.030 |
0.454 |
| AG |
143 (37.2) |
153 (39.8) |
0.96 (0.71-1.30) |
|
|
| GG |
62 (16.2) |
36 (9.4) |
1.77 (1.12-2.80) |
|
|
|
ATM: rs189037 (−111G/A) | |||||
| GG |
140 (36.5) |
125 (32.5) |
1.00 |
0.487 |
0.070 |
| GA |
186 (48.4) |
203 (52.9) |
0.78 (0.57-1.07) |
|
|
| AA | 58 (15.1) | 56 (14.6) | 0.88 (0.57-1.37) | ||
aAdjusted for age, gender, smoking and drinking status.
bFalse Discovery Rate (FDR) corrected P-value.
P < 0.05 for bold significances.