Table 1.
Fold changes in mRNA expression levels of genes in HEMECs compared to HDMVECs
| Gene symbol | Gene name | Accession number | FC |
|---|---|---|---|
| CTAG2 |
Cancer/testis antigen 2 |
NM_020994.3 |
11.6 |
| IL13RA2 |
Interleukin 13 Receptor, alpha 2 |
NM_000640.2 |
10.7 |
| IFI27 |
Interferon, alpha-inducible protein 27 |
NM_005532.3 |
8.3 |
| TPM2 |
Tropomyosin 2 (beta) |
NM_213674.1 |
7.8 |
| RPL14 |
Ribosomal protein L14 |
NM_001034996.1 |
6.6 |
| CCNA1 |
Cyclin A1 |
NM_003914.3 |
6.6 |
| RGS5 |
G-protein signaling 5 regulator |
NM_003617.3 |
6.0 |
| FBN2 |
Fibrillin 2 |
NM_001999.3 |
5.9 |
| D4S234E |
DNA segment on chromosome 4 (unique) |
NM_001040101.1 |
5.5 |
| BST2 |
Bone marrow stromal cell antigen 2 |
NM_004335.2 |
5.1 |
| QPCT |
Glutaminyl-peptide cyclotransferase |
NM_012413.3 |
4.8 |
| TNFSF4 |
Tumor necrosis factor (ligand) superfamily, member 4 |
NM_003326.3 |
4.6 |
| RGS5 |
Regulator of G-protein signaling 5 |
NM_003617.3 |
4.6 |
| SPOCK1 |
Sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1 |
NM_004598.3 |
4.6 |
| SNHG8 |
Small nucleolar RNA host gene 8 (non-protein coding) |
NR_003584.3 |
4.6 |
| ANTXR1 |
Anthrax toxin receptor 1 |
NM_032208.2 |
4.5 |
| CHST1 |
Carbohydrate sulfotransferase 1 |
NM_003654.5 |
4.5 |
| MPZL2 |
Myelin protein zero-like 2 |
NM_005797.3 |
4.4 |
| HEY2 |
Hairy/enhancer-of-spilt related with YRPW motif 2 |
NM_012259.2 |
4.3 |
| SLITRK4 |
SLIT and NTRK-like family, member 4 |
NM_173078.3 |
4.2 |
| SHISA2 |
Shisa homolog 2 |
NM_001007538.1 |
4.0 |
| LRRC17 |
Leucine rich repeat containing 17, TV2 |
NM_005824.2 |
3.9 |
| NUDT11 |
Nudix-type motif 11 |
NM_018159.3 |
3.8 |
| RNASE1 |
Ribonuclease, Rnase A family, 1, TV1 |
NM_198235.2 |
3.7 |
| SERPINE2 |
Serpin peptidase inhibitor, clade E, member 2 |
NM_006216.3 |
3.6 |
| LIPG |
Lipase, endothelial |
NM_006033.2 |
3.4 |
| PCSK5 |
Proprotein convertase subtilisin/kexin type 5 |
NM_006200.3 |
3.4 |
| LPXN |
Leupaxin |
NM_004811.2 |
3.3 |
| CXCR4 |
Chmeokine (C-X-C motif) receptor 4, TV2 |
NM_003467.2 |
3.2 |
| TMEM200A |
Transmembrane protein 200A |
NM_052913.2 |
3.1 |
| CXCR4 |
Chemokine (C-X-C motif) receptor 4, TV1 |
NM_001008540.1 |
3.1 |
| RAB34 |
RAB34, member RAS onogene family |
NM_031934.5 |
3.0 |
| DPYSL3 |
Dihydropyrimidinase-like 3 |
NM_001387.2 |
2.9 |
| FBXL13 |
F-box and leucine-rich repeat protein 13 |
NM_145032.3 |
2.9 |
| PNMA2 |
Paraneoplastic Ma antigen 2 |
NM_007257.5 |
2.9 |
| LOC440354 |
LOC440354 |
NR_002473.2 |
2.9 |
| NLGN1 |
Neuroligin 1 |
NM_014932.2 |
2.8 |
| DDIT4 |
DNA-damage-inducible transcript 4 |
NM_019058.2 |
2.8 |
| PFN2 |
Profilin 2 |
NM_053024.3 |
2.8 |
| GABBR2 |
Gamma-aminobutyric acid B receptor, 2 |
NM_005458.7 |
2.8 |
| MEIS2 |
Meis homeobox 2 |
NM_172315.2 |
2.7 |
| PMEPA1 |
Prostate transmembrane protein, androgen induced 1 |
NM_199169.2 |
2.7 |
| LOC647307 |
LOC647308 |
XR_039752.1 |
2.7 |
| PLEK2 |
Pleckstrin 2 |
NM_016445.1 |
2.7 |
| CARD11 |
Caspase recruitment domain family, member 11 |
NM_032415.4 |
2.6 |
| SNORD13 |
Small nucleolar RNA, C/D box 13, small nucleolar RNA |
NR_003041.1 |
2.6 |
| GFPT2 |
Glutamine-fructoce-6-phosphate transaminase 2 |
NM_005110.2 |
2.6 |
| FAP |
Fibroblast activation protein, alpha |
NM_004460.2 |
2.6 |
| OCIAD2 |
OCIA domain containing 2, TV2 |
NM_152398.2 |
2.5 |
| F2RL1 |
Coagulation factor II receptor-like 1 |
NM_005242.4 |
2.5 |
| DSTYK |
Dual serine/threonine and tyrosine protein kinase |
NM_199462.2 |
2.5 |
| LOC649497 |
LOC649498 |
XM_938576.1 |
2.5 |
| LOC654194 |
LOC654195 |
XM_942669.1 |
2.5 |
| NYNRIN |
NYN domain and retroviral integrase containing |
NM_025081.2 |
2.5 |
| LOC387763 |
LOC387764 |
XM_941665.2 |
2.5 |
| COL8A1 |
Collagen, type VIII, alpha 1 |
NM_020351.3 |
2.5 |
| MGC39900 |
MGC39901 |
XM_936687.1 |
2.4 |
| LTBP2 |
Latent transforming growth factor beta binding protein 2 |
NM_000428.2 |
2.4 |
| RNASE1 |
Ribonuclease, Rnase A family, 1, TV3 |
NM_198232.2 |
2.4 |
| IFI27L2 |
Interferon, alpha-inducible protein 27-like 2 |
NM_032036.2 |
2.4 |
| SOX4 |
SRY (sex determining region Y)-box4 |
NM_003107.2 |
2.4 |
| LRRC17 |
Leucine rich repeat containing 17, TV1 |
NM_001031692.2 |
2.3 |
| DSE |
Dermatan sulfate epimerase |
NM_013352.2 |
2.3 |
| CD44 |
CD44 molecule (Indian blood group), TV5 |
NM_001001392.1 |
2.3 |
| LOC100131139 |
LOC100131140 |
XR_037336.1 |
2.3 |
| CBS |
Systathionine-beta-synthase |
NM_000071.2 |
2.3 |
| NT5DC2 |
5'-nucleotidase domain containing 2 |
NM_022908.2 |
2.3 |
| NPFFR2 |
Neuropeptide FF receptor 2 |
NM_004885.2 |
2.3 |
| LOC100129685 |
LOC100129686 |
XM_001723814.1 |
2.3 |
| LXN |
Latexin |
NM_020169.3 |
2.3 |
| MEX3B |
Mex-3 homolog B |
NM_032246.3 |
2.3 |
| C1orf54 |
Chromosome 1 open reading frame 54 |
NM_024579.3 |
2.3 |
| HDDC2 |
HD domain containing 2 |
NM_016063.2 |
2.3 |
| LOC648823 |
LOC648824 |
XM_943477.1 |
2.3 |
| CYB5A |
Cytochrome b5 type A |
NM_001914.3 |
2.3 |
| PIR |
Pirin (iron binding nuclear protein) |
NM_001018109.2 |
2.3 |
| GPR37 |
G protein-coupled receptor 37 |
NM_005302.2 |
2.3 |
| PPAPDC1A |
Phosphatidic acid phosphatase type 2 domain containing 1A |
NM_001030059.1 |
2.3 |
| CD44 |
CD44 molecule (Indian blood group), TV4 |
NM_001001391.1 |
2.2 |
| LOC100131905 |
LOC100131906 |
XR_039334.1 |
2.2 |
| CTAG1A |
Cancer/testis antigen 1A |
NM_139250.1 |
2.2 |
| C4orf18 |
Chromosome 4 open reading frame 18 |
NM_016613.6 |
2.2 |
| LDOC1 |
Leucine zipper, down-regulated in cancer 1 |
NM_012317.2 |
2.2 |
| TGFBI |
Transforming growth factor, beta-induced |
NM_000358.2 |
2.2 |
| COL5A2 |
Collagen, type V, alpha 2 |
NM_000393.3 |
2.2 |
| NOX4 |
NADPH oxidase 4 |
NM_016931.3 |
2.2 |
| TSHZ3 |
Teashirt zinc finger homeobox 3 |
NM_020856.2 |
2.2 |
| FNDC3B |
Fibronectin type III domain containing 3B, TV2 |
NM_001135095.1 |
2.2 |
| KIT |
V-kit |
NM_001093772.1 |
2.2 |
| ADAM19 |
ADAM metallopeptidase domain 19 |
NM_033274.3 |
2.2 |
| JAM3 |
Junctional adhesion molecule 3 |
NM_032801.4 |
2.1 |
| CGNL1 |
Cingulin-like 1 |
NM_032866.4 |
2.1 |
| COL4A6 |
Collagen, type IV, alpha 6 |
NM_001847.2 |
2.1 |
| BMX |
BMX non-receptor tyrosine kinase |
NM_001721.6 |
2.1 |
| DUSP23 |
Dual specificity phosphatase 23 |
NM_017823.3 |
2.1 |
| MMP2 |
Matrix metallopeptidase 2 |
NM_004530.4 |
2.1 |
| NCAPD2 |
Non-SMC condensin I complex, subunit D2 |
NM_014865.3 |
2.1 |
| CYBRD1 |
Cytochrome b reductase 1, TV1 |
NM_024843.2 |
2.1 |
| FAM89A |
Family with sequence similarity 89, member A |
NM_198552.2 |
2.1 |
| GAS6 |
Growth arrest-specific 6 |
NM_000820.2 |
2.1 |
| S100A13 |
S100 calcium binding protein A13 |
NM_001024211.1 |
2.1 |
| SMARCE1 |
SWI/SNF related, subfamily e, member 1 |
NM_003079.4 |
2.1 |
| LOC643977 |
LOC643978 |
XM_932991.1 |
2.1 |
| LFNG |
O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase |
NM_001040167.1 |
2.1 |
| MTMR11 |
Myotubularin related protein 11 |
NM_181873.3 |
2.1 |
| ITGA10 |
Integrin, alpha 10 |
NM_003637.3 |
2.1 |
| PTGFRN |
Prostaglandin F2 receptor negative regulator |
NM_020440.2 |
2.0 |
| LOC644936 |
Actin, beta pseudogene |
NR_004845.1 |
2.0 |
| CPS1 |
Carbamoyl-phosphate synthase 1, mitochonfrial |
NM_001875.4 |
2.0 |
| C18orf56 |
Chromosome 18 open reading frame 56 |
NM_001012716.2 |
2.0 |
| ADA |
Adenosine deaminase |
NM_000022.2 |
2.0 |
| NETO2 |
Neuropilin and tolliod-like2 |
NM_018092.4 |
2.0 |
| DKFZp761P0423 |
DKFZp761P0424 |
XM_291277.4 |
2.0 |
| STC2 |
Stanniocalcin 2 |
NM_003714.2 |
2.0 |
| PRKAR1A |
Protein kinase, cAMP-dependent, regulatory, type I, alpha |
NM_002734.3 |
2.0 |
| EGFLAM |
EGF-like, fibronectin type III and laminin G domains |
NM_182801.2 |
2.0 |
| SPECC1 |
Sperm antigen with calponin homology, coiled-coil domains 1 |
NM_001033555.2 |
2.0 |
| FNDC3B |
Fibronectin type III domain containing 3B, TV1 |
NM_022763.3 |
2.0 |
| THOC3 |
THO complex 3 |
NM_032361.2 |
2.0 |
| COL5A1 |
Collagen, type V, alpha 1 |
NM_000093.3 |
2.0 |
| LANCL1 |
LanC lantibiotic synthetase component C-like 1 |
NM_006055.2 |
2.0 |
| OCIAD2 |
OCIA domain containing 2, TV1 |
NM_001014446.1 |
2.0 |
| LRIG1 |
Leucine-rich repeats and immunoglobulin-like domains 1 |
NM_015541.2 |
2.0 |
| HOXB2 |
Homeobox B2 |
NM_002145.3 |
2.0 |
| TIMP1 |
TIMP metallopeptidase inhibitor 1 |
NM_003254.2 |
−2.0 |
| NAAA |
N-acylethanolamine acid amidase |
NM_014435.3 |
−2.0 |
| MAOA |
Monoamine oxidase A |
NM_000240.2 |
−2.0 |
| MYOF |
Myoferlin |
NM_013451.3 |
−2.0 |
| KISS1 |
KiSS metastasis-suppressor |
NM_002256.3 |
−2.0 |
| SLC25A22 |
Solute carrier family 25, member 22 |
NM_024698.5 |
−2.0 |
| NOSIP |
Nitric oxide synthase interacting protein |
NM_015953.3 |
−2.0 |
| COL1A2 |
Collagen, type I, alpha 2 |
NM_000089.3 |
−2.0 |
| ZDHHC14 |
Zinc finger, DHHC-type containing 14 |
NM_024630.2 |
−2.0 |
| HPCAL1 |
Hippocalcin-like 1 |
NM_134421.1 |
−2.0 |
| VLDLR |
Very low density lipoprotein receptor |
NM_001018056.1 |
−2.0 |
| LOC730525 |
LOC730525 |
XM_001126202.1 |
−2.0 |
| BMP2 |
Bone morphogenetic protein 2 |
NM_001200.2 |
−2.0 |
| ABLIM1 |
Actin binding LIM protein 1 |
NM_006720.3 |
−2.0 |
| PIK3C2A |
Phosphoinositide-3-kinase, class 2, alpha polypeptide |
NM_002645.2 |
−2.0 |
| IRF1 |
Interferon regulatory factor 1 |
NM_002198.2 |
−2.0 |
| MBP |
Myelin basic protein |
NM_001025100.1 |
−2.0 |
| PRKAR1B |
Protein kinase, cAMP-dependent, regulatory type I, beta |
NM_002735.2 |
−2.1 |
| FAM101B |
Family with sequence similarity 101, member B |
NM_182705.2 |
−2.1 |
| ERCC2 |
DNA excision repair protein 2 |
NM_000400.3 |
−2.1 |
| CCND2 |
Cyclin D2 |
NM_001759.3 |
−2.1 |
| HLA-B |
Major histocompatibility complex, class I, B |
NM_005514.6 |
−2.1 |
| SYBU |
Syntabulin |
NM_001099743.1 |
−2.1 |
| PDE2A |
Phosphodiesterase 2A, cGMP-stimulated |
NM_002599.4 |
−2.1 |
| AKAP12 |
A kinase anchor protein 12 |
NM_005100.3 |
−2.1 |
| CLEC2B |
C-type lectin domain family 2, member B |
NM_005127.2 |
−2.1 |
| S100A4 |
S100 calcuim binding protein A4 |
NM_019554.2 |
−2.1 |
| FST |
Follistain |
NM_013409.2 |
−2.2 |
| SLC30A3 |
Solute carrier family 30, member 3 |
NM_003459.4 |
−2.2 |
| PLIN2 |
Perilipin 2 |
NM_001122.3 |
−2.2 |
| IL32 |
Interleukin 32 |
NM_001012633.1 |
−2.2 |
| LOC100128252 |
LOC100128253 |
XM_001725603.1 |
−2.2 |
| TIMM22 |
Translocase of inner mitochondrial membrane 22 homolog |
NM_013337.2 |
−2.2 |
| SYNM |
Synemin, intermediate filament protein |
NM_015286.5 |
−2.2 |
| LOC729985 |
LOC729986 |
XM_001131964.1 |
−2.2 |
| ADRB2 |
Adrenergic, beta-2-, receptor surface |
NM_000024.5 |
−2.2 |
| KIAA1274 |
KIAA1274 |
NM_014431.2 |
−2.2 |
| PRR5 |
Proline rich 5 |
NM_001017529.2 |
−2.2 |
| LOC387841 |
LOC387842 |
XM_932678.1 |
−2.3 |
| CFI |
Complement factor I |
NM_000204.3 |
−2.3 |
| LOC646836 |
LOC646837 |
XM_001718162.1 |
−2.3 |
| COL1A1 |
Collagen, type I, alpha 1 |
NM_000088.3 |
−2.3 |
| CCL2 |
Chemokine (C-C motif) ligand 2 |
NM_002982.3 |
−2.3 |
| COL6A1 |
Collagen, type VI, alpha 1 |
NM_001848.2 |
−2.3 |
| LOC201651 |
LOC201652 |
XR_017321.2 |
−2.3 |
| GALNTL4 |
GalNAc-T-like protein 4 |
NM_198516.2 |
−2.3 |
| S100A3 |
S100 calcuim binding protein A3 |
NM_002960.1 |
−2.4 |
| ALDH1A1 |
Aldehyde dehydrogenase 1 family, member A1 |
NM_000689.4 |
−2.4 |
| TNFRSF14 |
Tumor necosis factor receptor superfamily, member 14 |
NM_003820.2 |
−2.4 |
| CAV1 |
Caveolin 1 |
NM_001753.4 |
−2.4 |
| LAMC2 |
Laminin, gamma 2 |
NM_005562.2 |
−2.4 |
| NOSTRIN |
Nitric oxide synthase trafficker |
NM_052946.3 |
−2.4 |
| CEACAM1 |
Carcinoembryonic antigen-related cell adhesion molecule 1 |
NM_001024912.2 |
−2.4 |
| CYYR1 |
Cysteine/tyrosine-rich 1 |
NM_052954.2 |
−2.5 |
| SLC22A23 |
Solute carrier family 22, member 23 |
NM_021945.5 |
−2.5 |
| ACSL5 |
Acyl-CoA synthetase long-chain family member 5 |
NM_016234.3 |
−2.5 |
| AADAC |
Arylacetamide deacetylase |
NM_001086.2 |
−2.6 |
| COLEC12 |
Collectin sub-family member 12 |
NM_130386.2 |
−2.6 |
| KIAA1324L |
KIAA1324-like |
NM_152748.3 |
−2.6 |
| RNASET2 |
Ribonuclease T2 |
NM_003730.4 |
−2.6 |
| NXN |
Nucleoredoxin |
NM_022463.4 |
−2.6 |
| PLA2G4C |
Phospholipase A2, group IVC |
NM_003706.2 |
−2.6 |
| SERPINB2 |
Serpin peptidase inhibitor, clade B, member 2 |
NM_002575.2 |
−2.6 |
| CETP |
Cholesteryl ester transfer protein, plasma |
NM_000078.2 |
−2.7 |
| PLA2G16 |
Phospholipase A2, group XVI |
NM_007069.3 |
−2.7 |
| TNFSF18 |
Tumor necrosis factor superfamily, member 18 |
NM_005092.3 |
−2.8 |
| CITED2 |
Cbp/p300-interacting transactivator 2 |
NM_006079.3 |
−2.8 |
| C10orf116 |
Chromosome 10 open reading fame 116 |
NM_006829.2 |
−2.8 |
| PROX1 |
Prospero homeobox 1 |
NM_002763.3 |
−2.9 |
| PALM |
Paralemmin |
NM_002579.2 |
−2.9 |
| ZSCAN18 |
Zinc finger and SCAN domain containing 18 |
NM_023926.4 |
−2.9 |
| LEPREL1 |
Leprecan-like 1 |
NM_018192.3 |
−2.9 |
| CTSH |
Cathepsin H |
NM_004390.3 |
−2.9 |
| KHDRBS3 |
RNA-binding protein T-Star |
NM_006558.1 |
−3.0 |
| CDH11 |
Cadherin 11, type 2, OB-cadherin |
NM_001797.2 |
−3.1 |
| DDIT4L |
DNA-damage-inducible transcript 4-like |
NM_145244.3 |
−3.2 |
| GAPDHL6 |
GAPDHL7 |
XM_001726954.1 |
−3.2 |
| NR5A2 |
Nuclear receptor subfamily 5, group A, member 2 |
NM_003822.3 |
−3.3 |
| ABCA3 |
ATP-binding cassette, sub-family A, member 3 |
NM_001089.2 |
−3.3 |
| MARCH2 |
Membrane-associated ring finger 2 |
NM_001005416.1 |
−3.3 |
| CDKN2A |
Cyclin-dependent kinase inhibitor 2A |
NM_000077.4 |
−3.3 |
| MGP |
Matrix Gla protein |
NM_000900.3 |
−3.3 |
| ALDH1A2 |
Aldehyde dehydrogenase 1 family, member A2 |
NM_170697.2 |
−3.5 |
| HOXB7 |
Homeobox B7 |
NM_004502.3 |
−3.5 |
| EMCN |
Endomucin |
NM_016242.3 |
−3.5 |
| ANGPT2 |
Angiopoietin 2 |
NM_001147.2 |
−3.5 |
| GIMAP5 |
GTPase, IMAP family member 5 |
NM_018384.4 |
−3.6 |
| NDN |
Necdin homolog |
NM_002487.2 |
−3.8 |
| TACSTD2 |
Tumor associate calcuim signal transducer 2 |
NM_002353.2 |
−3.8 |
| KRT19 |
Keratin 19 |
NM_002276.4 |
−3.8 |
| FAM174B |
Family with sequence similarity 174, member B |
NM_207446.2 |
−3.9 |
| CECR1 |
Cat eye syndrome chromosome region, candidate 1 |
NM_177405.1 |
−4.2 |
| GPR116 |
G protein-coupled receptor 116 |
NM_015234.4 |
−4.3 |
| TNFRSF6B |
Tumor necrosis factor superfamily, member 6b, decoy |
NM_032945.2 |
−4.3 |
| PIEZO2 |
Piezo-type mechanosensitive ion channel component 2 |
NM_022068.2 |
−4.4 |
| UCHL1 |
Ubiquitin carboxyl-terminal esterase L1 |
NM_004181.4 |
−4.9 |
| KBTBD11 |
Kelch repeat and BTB domain containing 11 |
NM_014867.2 |
−5.3 |
| LOC375295 |
LOC375296 |
XM_374020.4 |
−5.5 |
| HSD17B2 |
Hydroxysteroid dehydrogenase 2 |
NM_002153.2 |
−8.4 |
| LYVE1 |
Lymphatic vessel endothelial hyaluronan receptor 1 |
NM_006691.3 |
−8.8 |
| PDPN |
Podoplanin |
NM_001006625.1 |
−15.8 |
| GYPC |
Glycophorin C |
NM_016815.3 |
−22.6 |
| MMP1 |
Matrix metallopeptidase 1 |
NM_002421.3 |
−25.8 |
| FABP4 |
Fatty acid binding protein 4, adipocyte |
NM_001442.2 |
−28.1 |
| CLDN11 | Claudin 11 | NM_005602.5 | −36.9 |