Fig. 2.

Circadian dysfunction is a common feature of mouse models of HD. Mice were placed individually in cages with running wheels, and locomotor activity was recorded under different lighting conditions. Each horizontal row represents an activity record for a 24-hr day. Successive days are plotted from top to bottom. The grey shading represents darkness. Mice were initially held in LD (12:12) and then released into DD. Panels show examples of the wheel-running activity recorded from WT (left), BACHD (middle). The average waveform of activity for each genotype (black line =WT; grey line = BACHD) as measured over 10-days in LD is also shown (right panel).The mice were 2-3 mo of age. Data from Kudo and colleagues⁸³.