Table 4.

Diagnosis accuracy of serum PCT, CRP, WBC, body temperature, ΔCRP and ΔPCT for diagnosis of ICU-acquired infection

	AUC	Cut-off level	Sensitivity (%)	Specificity (%)	PPV	NPV
PCT D0	0.84	1.86 ng/mL	68	91	68	91
CRP D0	0.88	88 mg/L	92	70	47	97
WBC D0	0.62	12120/mm3	64	68	36	87
Temperature D0	0.88	38.6°C	76	94	79	94
Composite score D0	0.90	28	80	97	87	94
ΔPCT	0.83	0.49 ng/mL	68	94	77	91
ΔCRP	0.85	12 mg/L	92	71	48	97

Data are presented as % unless otherwise stated. AUC: area under the receiver-operating-characteristic curve; NPV: negative predictive value; PPV: positive predictive value.