Table 3.
Demographic and clinical characteristics of the reported cases of hyperthyroid patients with hyperfunctioning thyroid carcinoma from the literature and the current case (n = 77)
| Characteristic | |
|---|---|
| Age |
|
| Mean—yr |
47.0 ± 19.8* |
| Distribution – no. (%) |
|
| < 15 yr |
6 (7.9%) |
| 15-30 yr |
10 (13.2%) |
| 31-45 yr |
20 (26.3%) |
| 46-60 yr |
15 (19.7%) |
| > 60 yr |
25 (32.9%) |
| Sex – no. (%) |
|
| Female |
60 (77.9%) |
| Male |
17 (22.1%) |
| High risk features |
|
| Historical – no. (%) |
0 (0%) |
| Ultrasonographical – no. (%) |
11 (36.7%) |
| Thyroid nodule size (via ultrasound or palpation) (cm) |
4.13 ± 1.68 |
| Thyroid carcinoma size on pathological review |
|
| Mean (cm) |
2.48 ± 1.70 |
| No. (%) with size < 1cm |
8 (20.5%) |
| Biochemical hyperthyroidism |
|
| T3 elevated – no. (%) |
39 (76.5%) |
| T4 elevated – no. (%) |
27 (51.9%) |
| Subclinical hyperthyroidism – no. (%) |
10 (13.0%) |
| Thyrotoxic symptoms – no. (%) |
37 (78.7%) |
| Compression symptoms – no. (%) |
5 (14.7%) |
| Thyroid scintigraphy |
|
| Technetium-99m-pertechnetate – no. (%) |
16 (24.2%) |
| Iodine-123 or −131 – no. (%) |
53 (80.3%) |
| Fine-needle aspiration |
|
| Benign – no. (%) |
7 (30.4%) |
| Malignant (or suspicious findings) – no. (%) |
10 (43.5%) |
| Follicular neoplasm – no. (%) |
2 (8.7%) |
| Nondiagnostic sample – no. (%) |
4 (17.4%) |
| FNA accordant with final pathological diagnosis – no. (%) |
12 (60%) |
| FNA not accordant with final pathological diagnosis – no. (%) |
9 (39.1%) |
| Type of thyroid carcinoma on surgical pathological review |
|
| Follicular thyroid carcinoma |
28 (36.4%) |
| Papillary thyroid carcinoma |
44 (57.1%) |
| Follicular variant of papillary thyroid carcinoma |
8 (18.2%) |
| Hurthle cell carcinoma |
6 (7.8%) |
| Insular cell carcinoma | 1 (1.3%) |
* Mean ± standard deviation.
no. = Number of subjects with this characteristic, % = percentage of subjects with this characteristic.