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. 2013 May 16;8(5):e63718. doi: 10.1371/journal.pone.0063718

Figure 3. Myeloid progenitors are functional targets of LPA.

Figure 3

A. LPA receptor mRNA expression in hematopoietic stem-progenitor cells (HSPC), common lymphoid (CLP) and myeloid progenitors (CMP) by qPCR. N = 4 independent experiments; *p<0.05. B. Migration in Transwell® experiments in the presence or absence of 18∶1 Oleoyl-LPA, 12 hours after seeding of HSPC, CMP or CLP. C. Proliferation of each cell type shown measured by 48 hour BrdU uptake. Y axis shows % of BrdU positive cells) D. Apoptosis of each cell type measured by the Annexin V assay (Y axis-shows the % of Annexin V positive cells). Mean ± SD; N = 3 independent experiments; *p<0.05.