Table 1. Demographic, clinical and MRI characteristics for controls (n = 25) and patients (n = 36).
| Controls | Patients | P | |
| Age (years) | 31±6 | 34±8 | NS |
| Gender (F/M) | 16/9 | 26/10 | NS |
| Disease Duration (years) | NA | 7.4±6.1 | NA |
| EDSS, median (range) | NA | 2.5 (1–4.5) | NA |
| DMT (y/n) | NA | 32/4 | NA |
| T2LV (mL) | NA | 7.3±8 | NA |
| GM (mL) | 679.5±64 | 636.6±52.6 | 0.006 |
| GM/ICV | 0.463±0.007 | 0.458±0.008 | 0.014 |
| WM (mL) | 487.7±47.7 | 448.3±44.6 | 0.002 |
| WM/ICV | 0.332±0.007 | 0.323±0.016 | 0.002 |
| CSF(mL) | 300.1±42 | 297.4±35.7 | NS |
| CSF/ICV | 0.20±0.010 | 0.21±0.016 | 0.004 |
| BPF | 0.79±0.01 | 0.78±0.02 | <0.001 |
| FA | 0.52±0.02 | 0.47±0.04 | <0.001 |
| MD (mm2/s) | 0.71±0.02×10−3 | 0.78±0.06×10−3 | <0.001 |
| AD(mm2/s) | 1.25±0.026×10−3 | 1.36±0.085×10−3 | <0.001 |
| RD(mm2/s) | 0.48±0.020×10−3 | 0.551±0.065×10−3 | <0.001 |
Mean±SD are shown, otherwise indicated. Chi-square was used to test difference in gender, whereas unpaired t-test was used to test all other measures. F = female, M = male, mL = millilitre, mm = millimetres, s = second, EDSS = expanded disability status scale, DMT = disease modifying therapy, T2LV = T2 lesion volume, GM = grey matter, WM = white matter, CSF = cerebrospinal fluid, ICV = intracranial volume, BPF = brain parenchymal fraction, FA = fractional anisotropy, MD = mean diffusivity, AD = axial diffusivity, RD = radial diffusivity, NS = not significant, NA = not applicable.