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. 2013 May 16;8(5):e63612. doi: 10.1371/journal.pone.0063612

Figure 1. Experimental protocol, opiate reward memory CPP expression and intra-BLA histological analysis.

Figure 1

A, Schematic summary of single-trial, acute morphine reward memory CPP conditioning procedure. B, Long-term stability of morphine single-trial CPP reward conditioning demonstrated by significant morphine-environment CPP up to 14 days post-conditioning. C , Microphotograph showing representative intra-BLA injector tip location (black arrows). D , Schematic summary of representative intra-BLA microinfusion sites for rats receiving intra-BLA ANI at 0 hrs (grey circles) or 12 hrs (white circles) post-conditioning. * = p<.05; ** = p<.01 for this and all subsequent figures. E, Schematic summary of representative intra-mPFC microinfusion sites for rats receiving intra-BLA ANI at 0 hrs (grey squares) or 12 hrs (black circles) post-conditioning. * = p<.05; ** = p<.01 for this and all subsequent figures.