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. 2013 May 16;8(5):e63612. doi: 10.1371/journal.pone.0063612

Figure 2. Effects of intra-BLA or mPFC anisomycin on temporal consolidation of acute opiate reward memory.

Figure 2

A, Post-conditioning intra-BLA microinfusions of ANI completely block consolidation of opiate reward memory when administered at 0 and 3 hrs, but has no effect at 6 or 12 hrs. A Morphine cue-recall control test administered 24 hrs after the initial CPP test in the 0 hr group does not re-store the memory. B, Post-conditioning intra-mPFC microinfusions of ANI completely block consolidation of opiate reward memory when administered at 12 hrs, but has no effect at time-points before this. A morphine cue-recall control test administered 24 hrs after the initial CPP test in the 12 hr group does not re-store the memory. C , Vehicle control groups for the effective time points of 0 hrs (intra-BLA) or 12 hrs (intra-mPFC) caused no block of morphine reward CPP memory consolidation. D, Temporally divergent effects of opiate reward memory consolidation interference presented as CPP difference scores (calculated as times in drug minus vehicle-paired environments).