Figure 3. Roles of ERK and CaMKII signalling during recent and remote opiate memory consolidation.

A , Relative to vehicle controls, both intra-BLA U0126 (0.1–1.0 µg/0.5 µl) and KN-62 (0.05–0.5 µg/0.5 µl), dose-dependently block opiate reward memory consolidation when administered at the 0 hr time point. B , Relative to vehicle controls, intra-mPFC KN-62, dose-dependently blocked opiate reward memory consolidation when administered at the 12 hr time point, while U0126 has no effect.