Figure 7. Effects of acute (0 hr) intra-BLA protein synthesis inhibition on behavioral CPP expression and mPFC neuronal activity.

A , Group data showing robust behavioral morphine CPP from rats receiving intra-BLA vehicle at 0 hrs post-conditioning. B , A sample rastergram from a single rat, showing typical mPFC neuronal associative responding across saline vs. morphine-paired environments during real-time CPP testing. C , Group data showing blockade of behavioral morphine CPP expression from rats receiving intra-BLA anisomycin at 0 hrs post-conditioning. D , Sample rastergram from a single rat, showing mPFC neuronal responding during real-time CPP testing, across saline or morphine-environmental exposure. Associative neuronal increases during morphine environmental exposure is absent, consistent with a lack of behavioral CPP expression.