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. 2013 May 16;7(5):e2222. doi: 10.1371/journal.pntd.0002222

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© 2013 Centurion-Lara et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Top: proteins encoded in the tprG locus. Bottom, proteins encoded in the tprJ locus. Regions of the same color indicate sequence identity among gene products. Five different variants can be identified among the 12 strains analyzed in the tprG locus. Nichols, Bal3 and Street 14 encode the Nichols reference TprG. Sea81-4encodes a truncated TprG. The TprGJ chimera is found in Mexico A, Samoa D, Gauthier and CDC2; the TprGI chimera is found in Iraq Band Bosnia A, and a truncated TprGI chimera is found in Cuniculi A and Fribourg-Blanc. At the tprJ locus, Nichols, Bal3, Mexico and Street 14 contain the Nichols TprJ. Sea81-4 and all non-syphilis strains carry theTprGJ hybrid. Green, signal peptide.