Figure 2. Association plots showing the −log10 P-values for SNPs tested against transcript expression levels of ILMN_1789596 probe in ETV6.

(a) shows the P-values for the dominance component of a 2df additive and dominance model and (b) P-values from an additive only 1df model. A genome-wide significant dominance only association is located on chromosome 12 (p12.3). The genotype-phenotype map for the top eSNP (rs12313805) (p = 1.12e⁻¹⁶) is given in (c). The over-dominance association was replicated (p = 2.54e⁻⁹) in an independent dataset (CDHWB_EA). (d) is the genotype-phenotype maps for rs12331805 in CDHWB_EA. The MAF for rs12313805 in BSGS and CDHWB_EA were 0.32 and 0.45, respectively.