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Dynamic cis and trans Regulation of Oct4 Gene[b] Expression A, cis-Regulation of the Oct4 PP, PE, and DE during embryonic development. B, The hyper-conserved Oct4-regulatory regions (PP, PE, DE) contain multiple response elements that mediate both Oct4 expression and repression upon differentiation. (ICM, inner-cell mass; Ex, extraembryonic ectoderm; EEc, embryonic ectoderm; VED, visceral endoderm; PC, proamniotic cavity; PGC, primordial germ cells).
