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Mechanistic model of Ednra regulation by progesterone. PRB dimer binds the PRE6 site and possibly another PRE element and interacts, along with Gata2 attached to the GATA2 site, with the preinitiation complex (PIC) containing the RNA polymerase II (Pol II) and the TFIID. These interactions may involve the mediator complex or other factors serving as intermediates between PRB/Gata2 and the PIC.
