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PKA stabilizes MYC in cells. A and B, PKA inhibition using H89 (10 mm, 1 h) decreased the MYC steady-state level in cells. C, PKA-specific peptide inhibitor PKI (20 mm, 1 h) destabilized MYC. D, PKA activation by forskolin (1 h) results in MYC accumulation. E, MYC mRNA level does not change upon H89 treatment (n = 3). F, PKA protects MYC from proteasome-mediated degradation. MG132 rescued the effect of PKA inhibition on MYC stability. DMSO, dimethyl sulfoxide.
