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In vitro neuronal cultures display sensitization to toxic insult with loss in Nur77 expression. A, mesencephalic WT and Nur77-deficient neuronal cultures treated with MPP+ for 24 and 36 h. B, cortical neuronal cultures treated with Nur77 and control siRNA (si-Ctl) and MPTP for 36 and 48 h. Error bars represent mean ± S.E. ANOVA, *, p < 0.05; **, p < 0.01; ***, p < 0.001; n = three embryos per group.
