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. 2013 Mar 27;288(20):14362–14371. doi: 10.1074/jbc.M112.439216

FIGURE 3.

FIGURE 3.

Nur77-deficient mice display increased dopamine cell bodies and striatal terminals of MPTP-induced degeneration of SNc dopaminergic neurons. A, representative photomicrographs illustrating TH immunoreactivity in the ventral midbrain SNc following indicated treatments. B, quantification of TH+ neurons using stereological analysis, as described under “Experimental Procedures.” C, quantification of cresyl violet-stained (CV) cells of the SNc (medial terminal nucleus (MTN) level). D, representative photomicrographs of striatal TH-immunoreactive sections from treated animal groups in A. E, quantification of striatal TH fiber optical density. F, representative photomicrographs of striatal DAT-immunoreactive sections from treated animal groups in A. G, quantification of striatal DAT fiber optical density. H, analysis of 24-h home cage locomotor activity for WT and Nur77-deficient mice. Error bars represent mean ± S.E. ANOVA, *, p < 0.05; **, p < 0.01; ***, p < 0.001; n = 6–8 animals per group. CV, cresyl-violet; OD, optical density.