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Schematic depicting post-translational modifications of Nrf2 after its separation from Keap1. For simplicity, phosphorylation (12, 84–86) has been deliberately omitted. Whether sumoylation of Nrf2 precedes its binding to the ARE or occurs after this event has not been determined. Ac, acetyl; O-Ac-ADP-Rib, O-acetyl-ADP-ribose; S, SUMO; U, ubiquitin.
