Table 2.

Phenotypes of representative mutants of AAC(6′)-Ib.

Mutationa	AAC(6′)-Ib variant name	Phenotype	References
Y80C		S	Panaite and Tolmasky, 1998
D117A		S	Pourreza et al., 2005
L119S	AAC(6′)-Ib′,	Specificity, Gmr Aks	Rather et al., 1992;
	AAC(6′)-Ib7,		Lambert et al., 1994;
	AAC(6′)-Ibb8		Casin et al., 2003
Q118L, L119S	AAC(6′)-Ib11	Specificity, Gmr Akr	Casin et al., 2003
L120A		S	Pourreza et al., 2005
Y166A		Specificity, Aks Kmr	Shmara et al., 2001
E167A		S	Shmara et al., 2001
F171A		S	Shmara et al., 2001
F171L		Thermosensitive for Ak and Nm	Panaite and Tolmasky, 1998; Shmara et al., 2001
W104R, D181Y	AAC(6′)-Ib-cr	Expanded substrate spectrum including quinolones	Robicsek et al., 2006

S, susceptible.

^aNumbering from sequence in accession number AF479774.

^bThe proteins differ at the amino terminus.