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KCNQ2/3 gene products (Kv7.2 and Kv7.3) form a heterotetramer channel at the axon initial segments (AISs) and nodes of Ranvier of neurons. Ankyrin-G (ANK3 gene product) links Kv7.2 and Kv7.3 to the underlying actin-βIV spectrin cortical cytoskeleton and mediates their co-localization via ankyrin-binding motifs at their C-terminal regions.
